Presentation:
Main causes: Infection, surgery, pregnancy, childbirth, tapering of MG meds, cholinergic crisis from high doses of mestinon >120mg q3-4hrs
Indication for ICU admission: Dyspnea when supine, severe dysphagia, hypophonia, pausing during speech for breath, increased RR, paradoxical breathing, baseline VC <20.
Drugs associated w/ exacerbation: Mg sulfate (inhibits ACh-esterase release), high dose prednisone, neuromuscular blockade, beta blocker, erythromycin, azithromycin-aminoglycoside, phenytoin, gabapentin, statin.